Nutritional supplements for Parkinson’s disease

While there is ongoing research about the potential benefits of various nutritional supplements for people with Parkinson's disease (PD), the evidence base for many of these supplements is still evolving.

Here are some supplements that have been studied for their potential effects on PD:

• Coenzyme Q10 (CoQ10): CoQ10 is an antioxidant that plays a role in energy production within cells. Some studies have suggested that CoQ10 might have neuroprotective effects and could potentially slow the progression of PD. However, the evidence is not yet conclusive, and more research is needed.

• Omega-3 Fatty Acids: Omega-3 fatty acids, found in fish oil and certain plant sources, have anti-inflammatory properties and may have potential neuroprotective effects. Also, a randomized control trial study found that patient’s that took fish oil had statistically significant improvements in depression.

• B Vitamins: Certain B vitamins, such as B6, B9 (folate), and B12, play roles in various cellular processes. Some studies have explored the potential benefits of B vitamin supplementation for PD. As we age, we may develop difficulty absorbing B12 from the gut, even if the amount in our food sources is adequate. Also, growing evidence suggests that a high daily dose of Carbidopa-Levodopa is associated with vitamin B6 deficiency. Screening for B6 levels is recommended if people are on a high daily dose of PD meds and/or have poor nutrition.

• Vitamin D: Vitamin D is important for bone health. People with PD often show nutrient deficiencies in vitamin D. Be sure to get your labs checked. It is important to eat an adequate intake of foods that provide vitamin D and of course, exposure to natural sunlight is key.

• Glutathione (GSH): GSH protects against oxidative stress. GSH deficiency has been identified as an early event in the progression of PD. A study concluded that GSH may slightly improve the motor scores of patients with PD. However, these conclusions warrant further investigation.

NOTE: It's important to approach nutritional supplements with the guidance of your medical team, especially considering potential interactions with medications and individual health conditions. The research on these supplements is continually evolving, and it's essential to rely on evidence-based information and the expertise of medical professionals when making decisions about supplement use. Always consult with your medical doctor before starting any new supplement regimen. These supplements are not meant to replace any existing medicine regime, but could serve as complementary therapies.

References:

Role of Diet and Nutritional Supplements in Parkinson's Disease Progression 

Parkinson Symptom Severity and Use of Nutraceuticals

Potential use of glutathione as a treatment for Parkinson's disease

https://www.apdaparkinson.org/article/nutrition-and-parkinsons-disease-part-one/